In Vivo Senior Scientist, Early Oncology Bioscience- Waltham, MA

Do you have expertise in, and a passion for discovering & delivering life-changing medicines to patients? Would you like to apply your expertise in TDE (Tumor Drivers, DNA Damage Response and Epigenetics), in a company that follows the science and turns ideas into life changing medicines? AstraZeneca might be the one for you!

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

At AZ, we’re proud to have an exceptional workplace culture that encourages innovation and collaboration. Here, employees are empowered to express diverse perspectives – and made to feel valued, energized and rewarded for their ideas and creativity. AZ is a place where passionate people can immerse themselves in their work and make significant contributions to scientific excellence and medicines – does this describe a place where you would like to work?

What you'll do:

• Use expert in vivo technical skills to support our growing epigenetics portfolio by:
  • Developing and working with various in vivo models of cancer ranging from subcutaneous xenograft tumor models, orthotopic models, and PDX models
  • Conducting in vivo pharmacology studies (tolerability, PK/PD and efficacy) and delivering comprehensive in vivo pharmacology data packages to support both early and late stage drug discovery programs
  • Performing model development studies to generate relevant in vivo models that support the screening cascade for a pathway of interest
• Demonstrate proficiency and flexibility in working with various computer programs and databases to capture all study data for broad access by project teams and stakeholders
• Profile tissue samples to explore mechanisms of drug response and resistance using both traditional and novel approaches
• Analyze data and present to appropriate stakeholders
• May sit on project teams and maintain responsibility for in vivo pharmacology strategy for a particular target

Education, Qualifications, Skills and Experience:

Essential Requirements:

• BS with 5+ years’ experience, MS or PhD with 2+ years’ experience
• Experience independently delivering aspects of in vivo pharmacology studies, including tolerability, PK/PD, model development, and efficacy studies
• Demonstrated ability to analyze PD response in various tissues including (but not limited to) blood and tumor
• Ability to harvest and prepare blood and tissues for various endpoints including processing for western blot analysis, PK, flow cytometry, and immunohistochemistry
• Ability to work independently, within project teams, and across disciplines
• Excellent communication and presentation skills

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big! Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

Site Description

Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park Bio Hub, just west of the city center. Our BioHub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world’s most vibrant research centers.

Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community.

So, what’s next?

A place built on courage, curiosity, and collaboration – we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take calculated risks that write the next chapter for our pipeline.

If you are swift to action, confident to lead, willing to collaborate, and passionate about the possibilities, then we are keen to hear from you!

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Next steps:

Apply today, or connect with our Talent Acquisition Partner – Kayla Harris: https://www.linkedin.com/in/kayla-harris-8723ab13b/ for a confidential discussion to explore this opportunity further. We are looking forward to hearing from you!