Scientist /Sr. Scientist - Structural and Computational Biology Job at Zoetis
The following base pay range reflects the anticipated base pay for this position if a selected candidate were to be located in Colorado. Base pay may vary based on location and other factors.
Base Pay Range: $94,000 - $116,000
[This position is eligible for short-term incentive compensation.] [The position is also eligible for long-term incentive.]
We offer a competitive and comprehensive benefits package, which includes healthcare, dental coverage, and retirement savings benefits along with paid holidays, vacation and disability insurance.
Zoetis is seeking a talented and experienced structural and computational biologist to contribute to our efforts in the Discovery Sciences and Technologies organization. This individual will partner with project teams to build therapeutic mechanisms of action through in vitro/ex-vivo assays, structure-based protein design, and computational modeling.
The successful candidate should have experience with biochemical and biophysical characterization of protein-protein interactions and relevant experience characterizing biological disease mechanisms. Familiarity with computational protein design tools, epitope mapping and molecular biology to provide actionable mechanistic insights is preferred. The candidate should be excited by research at the interface of computation, protein design, and biology, with the ability to define scientific problems and drive innovation to solve them. Excellent communication, organizational and interpersonal skills are essential. Some travel required.
POSITION RESPONSIBILITIES:
- Characterize biological mechanisms of action of large molecule therapeutics.
- Develop an understanding of protein interactions and target inhibition using high- and low-resolution structural biology, biochemical/biophysical methods (CryoEM/X-ray crystallography, HDX-MS, SAXS, ITC, SPR etc).
- Ab initio prediction of multimeric protein structures, interface identification, molecular dynamics and binding free energy calculation on HPC or cloud computing platform.
- Collaborate across multiple disease areas and groups such as protein sciences.
- Directly communicate with external partners for collaborations and outsourcing.
- Contribute to and drive publications, present results at internal and external meetings.
EDUCATION AND EXPERIENCE:
- Educational background: Ph.D. in structural biology, computational biology, molecular biology, biophysics, biochemistry, or related field; or M.S. with at least 5 years of relevant experience; or B.S with at least 10 years of relevant experience.
- Training or experience in biological sciences focusing on biophysical and biochemical characterization of proteins with an emphasis on resolution of large molecule structures.
- Expertise in structural biology and other biophysical methods to understand mechanism of protein action via methods such as single particle cryo-EM, X-Ray crystallography, NMR.
- Experience with protein modeling techniques including homology modeling, in silico protein design using tools such as Alphafold, Rosetta, MOE, Schrodinger etc.
- Exposure to protein expression & isolation (mammalian, yeast, insect & bacterial systems), affinity chromatography, protein biochemistry and protein quantification (SDS-PAGE protein gels, Westerns, analytical SEC, ELISAs, SPR) is a plus.
- Familiarity with Linux OS (install, configure and maintain) and working in high performance computing or cloud environments is a strong plus.
- Self-starter, able to prioritize work and work efficiently, design experiments with minimal supervision, and able work across teams remotely and face-to-face.
- Experience interacting with CROs or external partnerships
- Excellent verbal/written communication, organizational and interpersonal skills
- Computer skills required: Microsoft suite, Geneious or equivalent, protein modeling software (MOE, Rosetta, etc.),
ADDITIONAL INFORMATION:
We encourage you to apply even if you do not satisfy all criteria listed.
Work environment:
The placement of this position could be in Fort Collins, CO or Kalamazoo, MI. Occasional travel may be requested.
The person filling this position will work in a laboratory setting. There may be exposure to animal pathogens and chemicals. There may be handling of, and/or exposure to animal tissue and zoonotic organisms
Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Zoetis also complies with all applicable national, state, and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact.
Full time
Regular
Colleague
Any unsolicited resumes sent to Zoetis from a third party, such as an Agency recruiter, including unsolicited resumes sent to a Zoetis mailing address, fax machine or email address, directly to Zoetis employees, or to Zoetis resume database will be considered Zoetis property. Zoetis will NOT pay a fee for any placement resulting from the receipt of an unsolicited resume.
Zoetis will consider any candidate for whom an Agency has submitted an unsolicited resume to have been referred by the Agency free of any charges or fees. This includes any Agency that is an approved/engaged vendor but does not have the appropriate approvals to be engaged on a search.
Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. We offer reasonable accommodations as an alternative if requested by an individual with a disability. Please contact Zoetis Colleague Services at zoetiscolleagueservices@zoetis.com to request an accommodation. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact. Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of “@zoetis.com”. In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.
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